Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI
نویسندگان
چکیده
منابع مشابه
PANCREATIC NEUROENDOCRINE NEOPLASMS (pNENs)
Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare lesions that have been increasing in incidence over the past few decades largely because of the diagnosis of pancreatic incidentalomas on cross-sectional imaging. Most of these tumors are nonfunctioning presenting with symptoms secondary to mass effect, metastatic disease or as incidental findings. Diagnostic workup aims to assess ...
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INTRODUCTION Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare tumors representing 1% to 2% of all pancreatic neoplasms. These tumors can secrete a variety of biologically active substances giving rise to distinct clinical symptoms or can be clinically nonfunctioning. Apart from insulinomas and gastrinomas, which constitute the majority of functioning pNENs, some tumors may secret...
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In 1983, Gerdes, Schwab, Lemke and Stein reported upon a new monoclonal antibody which was generated by immunizing mice with nuclei of the Hodgkin lymphoma cell line L428. This antibody was found to label nuclei of proliferating cells including tumor cells. In their report the authors therefore concluded that “Ki-67 (a name derived from the city of Kiel where the authors worked, and the number ...
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BACKGROUND The incidence of pancreatic neuroendocrine neoplasms (pNEN) is increasing. This study aimed to evaluate predictors of overall survival and the indication for surgery. METHODS Data collected between October 2001 and December 2012 were analysed. Histological grading and staging was based on the classifications of the World Health Organization, the International Union Against Cancer a...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2018
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2018.8384